Saffron Consuming Side Effects and Safe Saffron Dosage
Author : Hamed Biglari | 2023 Dec 27

Saffron Consuming Side Effects And Safe Saffron Dosage

Saffron adds a lovely color to your food. It could add a significant boost to your health as well. Saffron has widespread traditional uses. It has demonstrated efficacy as an alternative treatment for mild to moderate depression. Anti-nociceptive and anti-inflammatory activity has been suggested. Saffron may also have a potential role in cancer treatment, reducing cardiovascular risk factors, and in age-related macular degeneration. The eminent Iranian medical scientists Razi and Avicenna introduced Saffron as a unique herbal plant for treating diseases such as depression, delivery difficulties, respiration insufficiency, and digestive disorders. Many pharmacological aspects of Saffron and its components, such as anti-hypertensive, anti-tremor, neuroprotective, anti-depressant antitussive, and anticonvulsant effects, have been investigated. Saffron is an excellent source of natural antioxidants that help protect our cells from damage.

Determining possible toxic effects is necessary regarding the wide use of Saffron and its active components in traditional medicine and current pharmacology. High Saffron consumption doses have health potential risks due to the accumulation of highly functional elements of Saffron's main constituents, such as crocin and safranal (two saffron components that act as antioxidants by preventing the formation of harmful molecules called free radicals) and others, such as Carotenoids, phenolic compounds, and flavonoids, etc. However, at lower doses (in drinks and meals), no specific side effects or allergic properties have been reported. Even in therapeutic doses of Saffron, it has exhibited no significant toxicity in clinical and experimental investigations.

Some studies report a few side effects, including dry mouth, dizziness, nausea, anxiety, tiredness, and changes in appetite and taste, but these symptoms are rare. As always, consult a qualified physician or botanist before adding a new and severe factor to your plant-based diet.

Excessive consumption of Saffron is harmful and reduces blood pressure and excessive blood thinning, vomiting, decreased heart rate, nosebleeds, bleeding eyelids and lips, and causes dizziness, lethargy, Jaundice, and other dangerous complications that can even lead to death.

Saffron might also not be the most cost-effective supplement, and some alternatives could be more desirable, but this valuation will differ considerably between individuals.

Just like with pharmaceutical drugs, chemicals in herbs can interact negatively with each other, and consumers must always be vigilant about their drug/herb combinations and seek professional advice.


Clinical studies have evaluated doses of pure Saffron ranging from 20 to 400 mg/day. Dosages of 1.5 g/day of Saffron are safe. Depression: 20 to 30 mg/day of saffron extract (stigma or petal) for mild to moderate depression. Hypertension: 400 mg/day of saffron tablets for seven days.

Excessive saffron intake can be harmful. Large doses of Saffron may have effects, including nausea and vomiting. Be cautious not to exceed recommended doses. Consuming over 5 grams of Saffron in a day is considered toxic. Also, exceeding 10 grams daily can lead to bleeding in the urinary and digestive systems or uterine stimulation that may result in an abortion. And ingesting more than 20 grams of saffron daily can be life-threatening.

* The FDA does not regulate supplements in the same way that drugs are. The FDA does not review these supplements for safety or efficacy before they hit the market.


It is contraindicated in bleeding disorders.


Avoid use. Amounts higher than those used in food (e.g., 5 g or more) have uterine stimulant and abortifacient effects. Information regarding safety and efficacy in lactation is lacking.

* Women who are pregnant or breastfeeding should not use Saffron.

InteracSaffronone is well documented.

Adverse Reactions

Reported adverse effects include nausea, vomiting, and headache. Allergic reactions are uncommon; however, occupational allergies, including rhino conjunctivitis, bronchial asthma, and cutaneous pruritus, have been reported. Case reports of anaphylaxis also exist.


Information is limited. Doses of 5 g are associated with toxic effects; amounts of 10 to 20 g may be fatal.


Hamed Biglari

Assistant Professor of Environmental Health Engineering in Gonabad University of Medical Sciences, Razavi Khorasan, Iran

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